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KMID : 0370019910050000055
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Chung-Ang Journal of Pharmacal Sciences
1991 Volume.5 No. 0 p.55 ~ p.63
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Effects of Methanol Extract and Water Extract of Euonymi Lignum Suberalatum on the Phagocytic Activity of Reticuloendothelial System and Carbon Deposition by Liver and Spleen of Mice
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Abstract
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Effects of methanol extract and water extract of Euonymi Lignum Suberalatum on the phagocytic activity of mouse reticuloendothelial system were studied by the carbon clearance method in normal mice and in carrageenan-treated mice.
The results obtained are as follows ;
1. In normal mice, the clearance-rate of carbon was significantly shortened 1 hour after the administration of water extract.(100, 200 and 400㎎/㎏, p.o., one time, one time/day for 2 days or one time/day for 3 days)
2. In carrageenan(inhibitor of macrophage activity)-treated mice, the clearance-rate of carbon was significantly shortened 1 hour after the administration of water extract.(100, 200 and 400㎎/㎏, p.o., one time/day for 3 days)
3. Water extract activated the phagocytosis of carbon by Kupffer cells in the liver(100, 200 and 400㎎/㎏, p.o., one time/day for 3 days) and by macrophage in the spleen.(100, 200 and 400㎎/㎏, p.o., one time/day for 3 days)
According to these results, water extract of Euonymi Lignum Suberalatum promotes the phagocytic activity on the reticuloendothelial system in mice and has a stimulatory effect on macrophage better than methanol extract does.
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